Saturday, April 27, 2013

Happiness tracking software could gauge mood in photos

SMILE ? you're on camera! If you want a quick way to pick out the happiest snaps from a wedding or judge the changing mood of a crowd, now there's software that can do it for you.

Developed by Abhinav Dhall at the Australian National University in Canberra and colleagues, the software analyses all the faces in a photo to give the shot an overall "mood score".

The team used face tracking software to analyse the smiles of the faces in a group by noting the positions of nine spots on the face such as the corners of the mouth and eyes. A machine learning algorithm, trained on photos that had been pre-labelled by humans, then used this data to give each face a smile intensity score.

The team also programmed the system to incorporate information from volunteers, who assessed how important the intensity of any individual's smile was to the overall mood score of a photo. Those who were standing near the centre of a picture were given a stronger weighting, for example, while partially obscured faces were less influential. When asked to gauge the happiness level of a photo, the system only deviated from the opinion of a human by around 7 per cent. The software was presented at the Conference on Multimedia Retrieval in Dallas, Texas, last week.

Dhall says the aim is to be able to assess the overall mood of a group from a single shot. By looking at a sequence of frames in a video, it could even gauge the mood of a crowd in real time. "If the mood score goes down over the time, we can assume that the group are getting angry," says Dhall. It could also be used to view albums on Facebook by arranging photos so the happiest ones are shown first, for example.

Ranael Kaliouby says the work fits well with what she is doing with her emotion analysis company, Affectiva. "I love the application ? namely, understanding and modelling the overall mood of a crowd," she says. "It gets us one step further to applying emotion measurement technologies in the real world."

This article appeared in print under the headline "Get your grin on to light up the happiness tracker"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Surprise! Michael Buble Performs in the NYC Subway

Michael Buble made an unexpected stop to promote his new album, To Be Loved: the New York City subway system! The 37-year-old Grammy-winner held an impromptu acapella show underground while joined by the band Naturally 7. The surprise concert took place at the W. 66 Street stop, and he performed his new ballad, "Who's Lovin' You." Watch it below!

Source: http://www.ivillage.com/michael-buble-performs-surprise-concert-nycs-subway/1-a-534429?dst=iv%3AiVillage%3Amichael-buble-performs-surprise-concert-nycs-subway-534429

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Tuesday, April 16, 2013

Heat set franchise home mark, top Bulls 105-93

Miami Heat's Norris Cole, left, Dwyane Wade, second from left, Chris Bosh, second from right, and LeBron James, right, watch from the bench during the first half of an NBA basketball game against the Chicago Bulls, Sunday, April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

Miami Heat's Norris Cole, left, Dwyane Wade, second from left, Chris Bosh, second from right, and LeBron James, right, watch from the bench during the first half of an NBA basketball game against the Chicago Bulls, Sunday, April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

Miami Heat's LeBron James 96) reacts after being called for an offensive foul during the first half of an NBA basketball game against the Chicago Bulls Sunday April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

Chicago Bulls' Kirk Hinrich (12) shoots as Miami Heat's Dwyane Wade (3) defends during the first half of an NBA basketball game on Sunday, April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

Chicago Bulls' Luol Deng, right, drives to the basket as Miami Heat's LeBron James (6) defends during the first half of an NBA basketball game Sunday April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

Chicago Bulls head coach Tom Thibodeau yells from the sideline during the first half of an NBA basketball game against the Miami Heat Sunday April 14, 2013, in Miami. (AP Photo/Lynne Sladky)

MIAMI (AP) ? LeBron James scored 24 points, Dwyane Wade added 22 and the Miami Heat set a franchise record for home wins in a season, topping the Chicago Bulls 105-93 on Sunday.

Mario Chalmers and Chris Andersen each scored 15 for Miami, which improved to 36-4 at home ? topping the 35-6 mark by the 2004-05 Heat. Miami held Chicago without a 2-point basket for the first 16 minutes of the second half, with the Bulls relying almost exclusively on 3-pointers.

Carlos Boozer finished with 16 points and 20 rebounds for the Bulls, who snapped Miami's 27-game winning streak last month. Chicago finished with 29 field goals and 30 fouls, allowing the Heat to shoot a season-high 41 free throws.

The loss keeps Chicago in the No. 6 spot in the Eastern Conference. Miami has wrapped up home-court advantage throughout the playoffs.

Chris Bosh had 12 points, nine rebounds and four blocks for Miami, which also got 11 points from Mike Miller. Luol Deng led Chicago in scoring with 19, Kirk Hinrich and Nate Robinson scored 14 apiece and Jimmy Butler added 13 for the Bulls, who shot just 35 percent.

Any Miami-Chicago game tends to be physical, and this was no exception. There were no fewer than six instances of Heat players ending up on the floor in the first 6 minutes alone, though Miami hardly seemed to be bothered by it all.

Wade, still working his way back from bone bruises around his right knee, tipped the ball away to start a break that resulted in a 3-pointer by Chalmers to give Miami a 16-9 edge. And moments later, Bosh head-faked Boozer into the air, then drove past for a two-hand dunk and a quick nine-point lead.

Heat coach Erik Spoelstra said before the game he would not play Bosh, Wade and James their usual big minutes, and wasn't kidding, with each of Miami's "Big Three" on the bench with 3:45 left in the opening quarter ? something that hardly ever happens.

James made his first seven shots, one of them a dunk off a bounce pass by Chalmers to give Miami a 46-31 lead midway through the second quarter. The dunk was with such force, Hinrich found himself flinching to get out of the ball's way.

The Bulls, still in a battle with Atlanta for the No. 5 seed in the East, bounced back fast. A 23-10 run to end the first half got Chicago within 56-54 at the break, and briefly took the lead when Jimmy Butler converted a four-point play to make it 61-60.

It didn't take long for Miami to regain control, with the lead at 86-77 entering the fourth.

NOTES: Bosh had four blocked shots, the sixth time he's done that since joining the Heat. ... Chicago allowed 30 first-quarter points for the third time in its last four games. ... The Heat bench went into hysterics in the second quarter, when a young boy who was drawn up to look like Andersen ? replete with the multi-colored neck tattoos ? was shown on the scoreboard screens throughout the arena. ... Butler, perhaps generously listed by the Bulls at 6-foot-7, took the opening tap against Bosh. Predictably, Bosh prevailed. ... Media outlets from France, Brazil, Puerto Rico, Colombia, Italy, Australia, China and Spain were among those in attendance.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-14-Bulls-Heat/id-2a42b2903bd747e5828b0ad4e62c520e

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Monday, April 15, 2013

High glucose levels could impair ferroelectricity in body's connective tissues

Apr. 15, 2013 ? High sugar levels in the body come at a cost to health. New research suggests that more sugar in the body could damage the elastic proteins that help us breathe and pump blood. The findings could have health implications for diabetics, who have high blood-glucose levels.

Researchers at the University of Washington and Boston University have discovered that a certain type of protein found in organs that repeatedly stretch and retract -- such as the heart and lungs -- is the source for a favorable electrical property that could help build and support healthy connective tissues. But when exposed to sugar, some of the proteins no longer could perform their function, according to findings published April 15 in the journal Physical Review Letters.

The property, called ferroelectricity, is a response to an electric field in which a molecule switches from having a positive to a negative charge. Only recently discovered in animal tissues, researchers have traced this property to elastin and found that when exposed to sugar, the elastin protein sometimes slows or stops its ferroelectric switching. This could lead to the hardening of those tissues and, ultimately, degrade an artery or ligament.

"This finding is important because it tells us the origin of the ferroelectric switching phenomenon and also suggests it's not an isolated occurrence in one type of tissue as we thought," said co-corresponding author Jiangyu Li, a UW associate professor of mechanical engineering. "This could be associated with aging and diabetes, which I think gives more importance to the phenomenon."

About a year ago, Li and collaborators discovered ferroelectric switching in mammalian tissues, a surprising first for the field. Ferroelectricity is common in synthetic materials and is used for displays, memory storage and sensors. Li's research team found that the wall of a pig's aorta, the largest blood vessel carrying blood to the heart, exhibits ferroelectric switching properties.

Li said that discovery left researchers with a lot of questions, including whether this property is found in other soft tissues and the health implications of its presence. Observing differences in ferroelectric behavior at the protein level has helped to answer some of those questions.

The research team separated the aortic tissue into two types of proteins, collagen and elastin. Fibrous collagen is widespread in biological tissues, while elastin has only been found in animals with a backbone. Elastin, as its name suggests, is springy and helps the heart and lungs stretch and contract. Ferroelectric switching gives elastin the flexibility needed to perform repeated pulses as with an artery.

When researchers treated the elastin with sugar, they found that glucose suppressed ferroelectric switching by up to 50 percent. This interaction between sugar and protein mimics a natural process called glycation, in which sugar molecules attach to proteins, degrading their structure and function. Glycation happens naturally when we age and is associated with a number of diseases such as diabetes, high blood pressure and arteriosclerosis, a thickening and hardening of the arteries.

The research team has focused solely on the aortic tissues, but this finding likely applies to other biological tissues that have the protein elastin, such as the lungs and skin.

"I would expect the same phenomena will be observed in those tissues and organs as well," Li said. "It will be more common than what we originally thought."

Researchers next will drill down even more to look at the molecular mechanics of ferroelectric switching and further try to connect the process with disease onset.

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The above story is reprinted from materials provided by University of Washington, via EurekAlert!, a service of AAAS.

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Journal Reference:

  1. Yuanming Liu, Yunjie Wang, Ming-Jay Chow, Nataly Q. Chen, Feiyue Ma, Yanhang Zhang, and Jiangyu Li. Glucose suppresses biological ferroelectricity in aortic elastin. Physical Review Letters, 2013 [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/BmO4yd38KHk/130415100855.htm

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Justin Bieber criticized for hoping Anne Frank would've been a 'belieber'

By Gael Fashingbauer Cooper, TODAY

Singer Justin Bieber stirred controversy over the weekend for claiming that Anne Frank, who wrote movingly of her years spent hiding from the Nazis, might have been a fan of his.

Staff of the Anne Frank House in Amsterdam, where Frank and family hid from the Nazis until they were betrayed in 1944,?posted on Facebook?that Bieber visited the landmark building.

The staff noted that Bieber signed the museum's guestbook with, "Truly inspiring to be able to come here. Anne was a great girl. Hopefully she would have been a belieber."

Facebook readers were not happy with Bieber's assumption.

"She would've been a WHAT?" wrote Kevin Garcia Leon. "That little idiot is way too full of himself. She's an important historical figure so show some respect."

"Way to turn an inspiring moment into something about yourself," wrote Meghan Mausteller.

On Monday, the Anne Frank House defended Bieber on the museum's Facebook page, with staff writing, "The Anne Frank House was pleased to welcome Justin Bieber to the Anne Frank House last Friday. We think it is very positive that he took the time and effort to visit our museum. He was very interested in the story of Anne Frank and stayed for over an hour. We hope that his visit will inspire his fans to learn more about her life and hopefully read the diary."

According to the Facebook page, fans waited outside the Amsterdam landmark just to see Bieber, who was in The Netherlands for a concert.

Frazer Harrison / Getty Images

Source: http://feeds.nbcnews.com/c/35002/f/653387/s/2ab84d49/l/0Ltodayentertainment0Btoday0N0C0Inews0C20A130C0A40C150C177493490Ejustin0Ebieber0Ecriticized0Efor0Ehoping0Eanne0Efrank0Ewouldve0Ebeen0Ea0Ebelieber0Dlite/story01.htm

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Experience The Brilliance Of Rebel Wilson In GIFs

FROM NEXT MOVIE Tomorrow, the epicness of Rebel Wilson will be fully realized when she takes the stage as host of the 2013 MTV Movie Awards. To fully prepare yourself for that schooling in ruling, we highly recommend that you take a look at the GIF collection that Next Movie has put together. The GIFs [...]

Source: http://moviesblog.mtv.com/2013/04/13/experience-the-brilliance-of-rebel-wilson-in-gifs/

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Sunday, April 14, 2013

Aung San Suu Kyi Visits Japan (Voice Of America)

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French religious right promises to spill blood over gay marriage push (Americablog)

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Beijing reports first case of new bird flu strain

BEIJING (Reuters) - Chinese capital Beijing reported on Saturday its first case of a new strain of bird flu, state news agency Xinhua said, the first time it has been found in a human outside of eastern China.

The seven-year-old child is in a stable condition in a Beijing hospital, the report said.

Two people who have had close contact with the child have shown no signs of being infected so far, Xinhua added.

A total of 11 people have died of the H7N9 bird flu strain since it was confirmed in humans for the first time last month, with 44 infections in all having been reported to date.

Shanghai and the eastern provinces of Zhejiang, Jiangsu and Anhui had been the only confirmed locations of infection until the Beijing case.

The source of infection remains unknown, though samples have tested positive in some birds in poultry markets that remain the focus of investigations by China and the U.N. Food and Agriculture Organization.

The new virus has caused severe illness in most of the people affected, leading to fears that if it becomes easily transmissible, it could cause a deadly influenza pandemic, though there has been no indication of that happening.

In a bid to calm public jitters over the virus, Chinese authorities have detained a dozen people for spreading rumors about the spread of bird flu.

(Reporting by Ben Blanchard; Editing by Daniel Magnowski)

Source: http://news.yahoo.com/beijing-reports-first-case-bird-flu-strain-013210453.html

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Saturday, April 13, 2013

Snedeker, Cabrera tied for lead at Masters

AUGUSTA, Ga. (AP) ? Tiger Woods made two significant moves Saturday at the Masters ? one to stay in the tournament, the other to stay in the hunt.

A day filled with high drama before a shot was struck at Augusta National, ended with Brandt Snedeker and Angel Cabrera tied for the lead, and Woods only four shots back. For a few tense hours in the morning, it was not clear if Woods was going to get a chance to play.

Masters officials discovered late Friday evening that Woods had taken a bad drop in the second round and should have added two shots to his score.

Under normal circumstances, he would have been disqualified for signing an incorrect card. Officials took the blame for not alerting Woods to a potential problem ? they found nothing wrong at first glance before he signed ? and kept him in the tournament with two shots added to his score. Woods was covered under a 2-year-old rule that prevents DQs when a violation is reported by television viewers.

"It certainly was a distraction early," Woods said after three birdies on his last seven holes for a 70. "It happens and you move on. I was ready to play come game time."

So was Snedeker.

He's been building toward a moment like this for the last year, and he seized his chance on a glorious afternoon with a bogey-free round of 3-under 69. After opening with 12 pars, he birdied both the par 5s and stuffed his tee shot to 4 feet for birdie on the par-3 16th to take the lead. Cabrera joined him at 7-under 209 with a 12-foot birdie putt on the final hole, capping off a round in which he twice made bogey on the par 5s.

They were two players going in opposite directions this year. Snedeker was seen as the hottest player in golf when in three straight weeks he was runner-up to Woods, runner-up to Phil Mickelson and then won at Pebble Beach. His momentum was slowed by sore ribs that kept him out of golf for a month, though he appears to be hitting his stride.

"I've spent 32 years of my life getting ready for tomorrow," Snedeker said. "I'm going to be disappointed if I don't win. Period. I'm not here to get a good finish. ... I'm here to win."

Cabrera, whose two major titles include a Masters win in 2009, has plunged to No. 269 in the world.

"I've been working very hard for this moment," Cabrera said through an interpreter. "And I've got to take the opportunity."

For Adam Scott, it's a chance at redemption.

He was runner-up at the Masters two years ago, though the fresher wounds are from last summer at Royal Lytham & St. Annes, where the Australian bogeyed his last four holes and finished one shot behind in the British Open. Scott rammed home a 25-foot birdie putt on the 17th hole for a 69 and was one shot behind.

Two more Aussies, Marc Leishman (72) and Jason Day (73) were another shot behind, giving the blokes from Down Under as good a chance as ever to give their country some happy memories from Augusta National. It's the only major an Australian has never won, a point driven home with every mention of Greg Norman losing a six-shot lead on the last day in 1996.

"Obviously, to win the Masters would be incredible," Scott said. "It would be great for Australia. We've never looked better odds-wise going into a Sunday, except that one year in 1996. It's going to be a hell of a round tomorrow."

Day was in the lead for most of the day, going 18 straight holes without a bogey until he missed short par putts on the last two holes.

Matt Kuchar (69) was three shots back, and Woods was right behind.

Woods, the No. 1 player in the world who already has won three times this year, was the heavy favorite going into the Masters to capture a green jacket for the first time since 2005 and end his five-year drought in the majors.

His big move came after a bogey on the 11th hole, leaving him six shots behind as he made his way through a back nine that has not treated him kindly of late. But he ran off three birdies on the next four holes, and made clutch par saves on the 16th and 18th to stay in the game.

"I'm right there in the ball game, "Woods said. "I'm four back with a great shot to win this championship."

History is not on his side. Woods has never won a major from behind, every Masters champion has been no worse than a tie for fourth going into Sunday dating to Faldo's comeback in 1989. But at least he's still in the game.

That was never in doubt to the officials running the Masters. Fred Ridley, chairman of the competition committees, said he looked at video as Woods was playing the 18th hole Friday and saw no need to ask him about the drop because he didn't detect a violation. It was only after Woods' post-round interview when he implicated himself by saying he went back a few yards by design that it became an issue.

Because he saw no problem at first with the drop and let Woods sign his card without talking to him, Ridley said it would have been "grossly unfair to Tiger to have disqualified him." He said the notion of a DQ was "not even on the table."

Woods couldn't have been too shaken up by the morning activities. He birdied the first hole. The key for everyone was simply to stay somewhere around contention, and that wasn't easy. Rory McIlroy was only three shots out of the lead when he took a bogey on the seventh hole. Little did Boy Wonder realize that it would start a nasty cycle. With a pair of 7s on his card on the back nine ? wind shifts led to a triple bogey on the 11th and a double bogey on the 15th ? he shot 42 on the back for a 79.

"I play 7 through 11 in 5-over par and basically my chances in the tournament are gone," McIlroy said. "So it's very disappointing. I feel like I have been playing well coming in here and it's just a frustrating day here."

Former PGA champion Keegan Bradley had an 82, while Mickelson shot 40 on the back nine for the second straight day and had a 77. Guan Tianlang, the 14-year-old from China, went his second straight round without a birdie and had a 77. He was still smiling, soaking in his weekend at Augusta as the youngest player to make a cut in a PGA Tour-sanctioned tournament.

Meanwhile, Snedeker takes an amazing streak into the final round. He has gone 27 consecutive holes without a bogey at Augusta National, and he has a clear plan of what he needs to do be fitted for a green jacket.

"If I drive the ball in the fairway and play the par 5s well tomorrow, I'm going to have a really good day."

Source: http://news.yahoo.com/snedeker-cabrera-tied-lead-masters-232455720--spt.html

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Monday, April 8, 2013

3Gbps LED light bulb WLAN acheived by Fraunhofer Heinrich Hertz Institute

Image

We first noted it back in 2008: the possibility of using LED light bulbs for secure and directional wireless internet access. Well, the Fraunhofer Heinrich Hertz Institute is claiming that speedy data rates of up 3Gbps have proven feasible in its labs. The boost comes from its latest enhancements, allowing the 180Mhz frequency to be used over the usual 30Mhz, which apparently leaves extra room for moving data. If you'll recall, that's a significant leap over the 800Mbps top speed it achieved back in 2011 mixing various light colors. While this IR-like take on wireless internet access gains steam, remember that it's more likely to be used in areas where WiFi radios cause interruptions (hospitals, trade shows like CES, etc.) -- rather than a strip of mini spot lights from IKEA for the casa. (We can dream, can't we?) FHHI plans to show off the new gear at FOE '13, but for now you'll find the full press release after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/bsSjGRWl76M/

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Lenovo IdeaTab Lynx review: a decent Windows 8 tablet, but not Lenovo's best

Lenovo IdeaTab Lynx review: a decent Windows 8 tablet, but not Lenovo's best

If Windows 8 tablets with Intel's Clover Trail silicon under the hood were once a curiosity, well, they're certainly not novelties anymore. We've seen lower-powered hybrids from virtually every PC maker, providing a cheaper counterpoint to Core i5 and i7 systems, but still offering useful accessories like keyboard docks. In addition to one of our favorite Atom-powered slates, the ThinkPad Tablet 2, Lenovo is shilling the IdeaTab Lynx (also known as the IdeaTab K3011) for $549 and up. So how does this system stack up? Click through to find out.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/cND6FgbAdyc/

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Sunday, April 7, 2013

'She was doing what she loved': Young diplomat among 6 Americans killed in Afghanistan

Diplomat Anne Smedinghoff was among the six Americans killed in two separate attacks in Afghanistan on Saturday -- the deadliest day for Americans in that country since August. NBC's Ron Mott reports.

By Marian Smith, NBC News

Family, friends and State Department colleagues on Sunday were mourning the first death of an American diplomat on duty since Ambassador Chris Stevens was killed in the attack on the U.S. Consulate in Benghazi, Libya on Sept. 11 last year.

Anne Smedinghoff, 25, was one of five Americans killed in a car bomb attack on Saturday in Zabul Province, Afghanistan, Secretary of State John Kerry said Sunday. Three of the dead were U.S. service members and the fifth a civilian employee of the Defense Department, Kerry said.

They had not been named as of Sunday morning.

Several Afghans and four other State Department employees were injured, one critically.

A sixth American civilian working with the U.S. government was killed in a separate attack in eastern Afghanistan on Saturday, ISAF said in a statement.

"It's a grim reminder to all of us, though we didn't need any reminders, of how important and also how risky carrying the future is with people who want to resist," Kerry told State Department employees on Sunday during a visit in Istanbul, Turkey.

Smedinghoff and the other Americans were traveling in a convoy to southern Afghanistan to deliver textbooks to children in Qalat, Kerry said.?

Buzkashi Boys is an intense, gritty film made in Afghanistan about two street children. After numerous international awards, the movie is now eligible to be nominated for an Academy Award. ITN's Emma Murphy reports.

He met the Illinois-native several weeks ago when she worked as his control officer during his recent trip to Afghanistan.?He described her as "vivacious, smart, capable."

"There are no words for anyone to describe the extraordinary harsh contradiction for a young 25-year-old woman, with all of her future ahead of her, believing in the possibilities of diplomacy to improve people's lives, making a difference, having an impact" to be killed, Kerry said.

He described Smedinghoff as "a selfless, idealistic woman who woke up yesterday morning and set out to bring textbooks to school children, to bring them knowledge."

Smedinghoff previously served in Venezuela.

In an email to the Washington Post, Smedinghoff's parents said their daughter "was always looking for opportunities to reach out and help to make a difference in the lives of those living in a country ravaged by war."

The two Afghan teens who starred in the short critically acclaimed film 'Buzkashi Boys' landed at LAX this week to attend the Oscars. It was a far cry from their home country, where one of the boys ? Fawad ? sold maps on the streets to help support his family. NBC's Kristen Dahlgren reports.

They added: "We are consoled knowing that she was doing what she loved, and that she was serving her country by helping to make a positive difference in the world."

Smedinghoff recently helped NBC News coordinate a report on "Buzkashi Boys," the short film nominated for an Oscar starring an Afghan boy who was discovered on the streets of Kabul.

Local Afghan producer Khyber Shinwari described her as "a lovely lady, charming ? smiling on her face."

"She was very open and so helpful. So kind," he said. "She was here to help Afghans."

The Taliban claimed responsibility for the Zabul attack in a text message Saturday. The assault came just three days after 54 people were killed in another Taliban attack on a courtroom in the western Farah province of Afghanistan.

The United Nations has said civilians are increasingly being targeted this year.

On his first day in office, Kerry said the safety of State Department employees was a top priority, in the wake of the attack that killed Ambassador Stevens and three other Americans in Benghazi. No one has been convicted as of yet.

NBC News' Jamieson Lesko, Kiko Itsaka and Catherine Chomiak, and The Associated Press and Reuters contributed to this report.

Related:

'We have to go': Afghans ready to flee country as foreign troops withdraw

54 killed, 90 wounded in attack on Afghan compound

Tears of joy: The moment an Afghan teen learned of Oscar nomination

Source: http://feeds.nbcnews.com/c/35002/f/653387/s/2a6dc143/l/0Lworldnews0Bnbcnews0N0C0Inews0C20A130C0A40C0A70C17640A3110Eshe0Ewas0Edoing0Ewhat0Eshe0Eloved0Eyoung0Ediplomat0Eamong0E60Eamericans0Ekilled0Ein0Eafghanistan0Dlite/story01.htm

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EU: No deal reached at nuclear talks with Iran

Secretary of Iran?s Supreme National Security Council, Saeed Jalili grimaces while listening to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili grimaces while listening to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

EU foreign policy chief Catherine Ashton leaves her news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili listens to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili prepars to listen to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

EU foreign policy chief Catherine Ashton answers a question during her news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

(AP) ? Iran and six world powers failed to reach agreement Saturday on how to reduce fears that Tehran might use its nuclear technology to make weapons, extending years of inconclusive talks and adding to concerns the diplomatic window on reaching a deal with Tehran may soon close.

Expectations the negotiations were making progress rose as an afternoon session continued into the evening. But comments by the two sides after they ended made clear that they fell far short of making enough headway to qualify the meeting as a success.

"What matters in the end is substance, and ... we are still a considerable distance apart," Catherine Ashton, the European Union's head of foreign policy, told reporters at the end of the two-day talks.

Ashton, the convener of the meeting, said negotiators would now consult with their capitals. She made no mention of plans for new talks ? another sign that the gap dividing the two sides remains substantial. She said she would talk with chief Iranian negotiator Saeed Jalili by telephone over further steps.

Jalili spoke of "some distance between the positions of the two sides." He suggested Iran was ready to discuss meeting a key demand of the other side ? cutting back its highest-grade uranium enrichment production and stockpile ? but only if the six reciprocated with rewards far greater than they are now willing to give.

While no breakthrough had been expected, the lack of forward movement in international negotiations that started a decade ago was certain to increase concerns that diplomacy was ineffective as a tool to stop Iran from moving toward nuclear-weapon making capacity.

Israel is most worried. The Jewish state says Iran is only a few months away from the threshold of having material to turn into a bomb and has vowed to use all means to prevent it from reaching that point. The U.S. has not said what its "red line" is, but has said it will not tolerate an Iran armed with nuclear weapons.

"The Iranians are using the round of talks to pave the way toward a nuclear bomb," said Yuval Steinitz, the Israeli minister for intelligence and strategic affairs, in a text message to reporters. "Israel has already warned that the Iranians are taking advantage of the rounds of talks in order to buy time to advance in uranium enrichment, step by step, toward a nuclear weapon."

Urging the international community to set a "short, clear and final timetable" for further talks, he said "the time has come for the world to show a more aggressive position and make it abundantly clear to the Iranians that their game of negotiations is coming to an end."

Any strike on Iran could provoke fierce retaliation directly from Iran and through its Middle East proxies in Syria, Lebanon and Palestine, raising the specter of a larger Middle East conflict and adding to the urgency of keeping both sides at the negotiating table.

At the talks in the Kazakh city of Almaty, the U.S., Russia, China, Britain, France and Germany were asking Tehran to greatly limit its production and stockpiling of uranium enriched to 20 percent, which is just a technical step away from weapons-grade uranium. That would keep Iran's supply below the amount needed for further processing into a weapon.

But the group views that only as a first step in a process. Iran is operating more than 10,000 centrifuges. While most are enriching below 20 percent, this material, too could be turned into weapons-grade uranium, although with greater effort than is the case for the 20-percent stockpile.

Tehran also is only a few years away from completing a reactor that will produce plutonium, another pathway to nuclear arms.

The U.N. Security Council has demanded a stop to both that effort and all enrichment in a series of resolutions since 2006. Iran denies any interest in atomic arms, insists its enrichment program serves only peaceful needs, says it has a right to enrich under the Nuclear Nonproliferation Treaty and describes U.N. Security Council demands as illegal.

The lack of progress at Almaty was a clear indication that Tehran wants greater rewards for any concessions that the six are ready to give. Among other incentives, they have offered to lift sanctions on Iran's gold transactions and petrochemical trade. But Iran demands much more substantial sanctions relief, including an end to international penalties crippling its oil trade and financial transactions

A senior U.S. official cited Iranian officials who described the six-power offer of limited sanctions relief in exchange for meeting their demands on 20-percent uranium as a "turning point" when the two sides met last month. The official said the U.S. administration was "disappointed that this rhetoric did not carry over into our negotiations."

The official demanded anonymity as a condition for participation in a post-meeting briefing for reporters.

Jalili in turn urged the six powers to demonstrate their "willingness and sincerity" by taking appropriate confidence-building steps in the future" ? shorthand for Iran's demand to lift major sanctions and offer other concessions.

At the same time, he suggested some potential give on the Iranian side, suggesting discussion on some curbs of 20-percent enrichment "can be continued in the talks" if the six "move away from hostile treatment ... of the Iranian people."

With Iran previously describing the crushing sanctions on its oil exports and financial transactions as hostile acts, his comments suggested that Iran would consider compromise only if those penalties were lifted. That is far more than the relief being offered, with the six prepared to remove sanctions only on Tehran's gold transactions and petrochemical exports.

In demanding recognition of its right to enrich, Iran may hope to exploit some differences among the six, with Russia in recent months pushing for concessions on that point as a way to break negotiating deadlock.

Russian Deputy Foreign Minister Sergei Ryabkov, who led his country's delegation at Almaty, said after the talks that Moscow "considers that it's necessary to recognize all rights of Iran, including enrichment." In exchange, he said Iran must accept more international monitoring of its nuclear program.

A British Foreign Office statement said "a wide gap remains between the parties. Iran's current position falls far short of what is needed to achieve a diplomatic breakthrough."

Indirectly warning of further sanctions, the statement urged Tehran to "consider carefully whether it wants to continue on its current course, and face increasing pressure and isolation from the international community, or to enter into meaningful negotiations."

But Ryabkov described the meeting as "undoubtedly a step forward." Those remarks, and his comments on enrichment, both to Russian news agencies, suggested differences exist among the six, despite assertions by negotiators from Western nations of total unity at the negotiations.

___

Associated Press writers Mansur Mirovalev in Almaty, Daniel Estrin in Jerusalem, James Heinz in Moscow and Cassandra Vinograd in London contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-06-Iran-Nuclear/id-eca2d81ea7ea465587551db750fefc02

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Saturday, April 6, 2013

Penn Medicine's new center for personalized diagnostics unlocks cancer's secrets

Apr. 5, 2013 ? Just like a massive iceberg jutting out of the ocean, many of cancer's genetic underpinnings remain hidden under the surface, impossible to predict or map from above. The foreboding shadows and shapes that appear on CT scans and MRIs -- and even in the field that doctors see when they zoom in to look at cancer cells under a high-powered microscope -- are just the tip of the iceberg.

Penn Medicine's new Center for Personalized Diagnostics, a joint initiative of the department of Pathology and Laboratory Medicine in the Perelman School of Medicine and the Abramson Cancer Center, is diving deeper into each patient's tumor with next generation DNA sequencing. These specialized tests can refine patient diagnoses with greater precision than standard imaging tests and blood work, all with an aim to broaden treatment options and improve their efficacy.

"We're using the most advanced diagnostic methods to unlock cancer's secrets," says David B. Roth, MD, PhD, chairman of the department of Pathology and Laboratory Medicine. "A tumor's genomic profile is the most critical piece of information for an oncologist to have when they're deciding what therapy to recommend. The results of tests in the Center for Personalized Diagnostics reveal a genetic blueprint of each patient's tumor that is as discrete and singular as a fingerprint."

The Center for Personalized Diagnostics unites top experts in genomic analysis, bioinformatics, and cancer genetics -- who use the most sensitive data analysis tools available to identify the rarest of mutations -- with oncologists who treat patients and design clinical trials to test new therapies. Together, their efforts will provide cancer patients with cutting-edge diagnostic and therapeutic options.

The first group of patients who are undergoing testing through the CPD includes those with blood cancers and solid tumors of the brain, melanoma, and lung. Throughout 2013, the tests will be expanded for a wider range of cancer patients. Results are available within two weeks -- twice as fast as most commercially available testing panels. All new and relapsed Abramson Cancer Center patients will receive this testing -- conducted via simple blood tests and/or biopsy of tumor tissue or bone marrow -- as part of their evaluation and diagnostic process. Interpretation of results is communicated one-on-one to patients and their caregivers by physicians and genetic counselors.

In contrast to the CPD's offerings, individual genetic tests -- which now proliferate in the marketplace, even for healthy people who may be interested in going on a spelunking expedition through their DNA -- are time consuming and expensive to conduct, and they often yield information which is not clinically actionable. When these tests are offered for cancer patients, patients are often left with only a veritable alphabet soup detailing genetic information, with few plans for how to use those findings to conquer their cancer.

Since the CPD began operating in early 2013, however, tests in 80 percent of patients revealed genetic mutations that may be used to alter their treatment course or clarify their prognosis. The results are playing a role in:

  • Matching patients with existing therapies designed to target mutations previously associated only with different cancers. For instance, some lung cancer patients exhibit mutations of the BRAF gene, which is targeted by drug Vemurafenib, initially developed and approved for melanoma. Testing in the Center for Personalized Diagnostics is helping clinicians make new connections that will expand the indications for existing drugs.
  • Helping physicians determine which treatments a patient will respond to, or how well they will tolerate a particular treatment. Patients with the blood cancer acute myelogenous leukemia who express a mutation known as DNMT3A, for instance, are known to respond to higher doses of the drug daunorubicin. Learning this type of information prior to beginning treatment can help oncologists select and dose drugs in a way that will reduce side effects and boost patients' quality of life during treatment -- and increase their chance of completing their prescribed regimen.
  • Identifying patients who are likely to have a poor prognosis if treated with first-line therapies, which allows clinicians to set up a cascade of alternative therapies or, in the case of some blood cancer patients, expedite the search for a matching bone marrow donor.
  • Detecting resistance mutations that could slow or halt patients' response to targeted drugs, which allows for custom-designed combination therapies to attack tumors through multiple pathways.

The Center's research agenda operates in parallel with its clinical care mission. Each patient's test results will add to an enormous repository of genomic mutation profiles that, combined with the ability to follow patients over time, will help clinical researchers identify new markers and mutation profiles to better predict the course of an individual patient's treatment response and suggest new targets for therapy. As new mutations are detected and novel treatment options are identified, the gene testing panels will be modified and expanded, creating an evolving, real-time mutation profiling option.

"We see 11,500 newly diagnosed patients each year in the Abramson Cancer, and hundreds of others who seek our help when their cancers have not responded, or have returned, after receiving standard therapies elsewhere," said Chi Van Dang, MD, PhD, director of the Abramson Cancer Center. "A key part of our mission is to provide each of these patients these tests as soon as possible, so that we can quickly tailor a treatment regimen that provides them the greatest chance of a cure."

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The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/m4ztSlvAFzs/130405104723.htm

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Friday, April 5, 2013

He was a splendid military gambler, dominating the problems of...

He was a splendid military gambler, dominating the problems of supply and scornful of opposition?? His ardor and daring inflicted grievous disasters upon us, but he deserves the salute which I made him ? and not without some reproaches from the public ? in the House of Commons in January 1942, when I said of him, ?We have a very daring and skillful opponent against us, and, may I say across the havoc of war, a great general.?

He also deserves our respect because, although a loyal German soldier, he came to hate Hitler and all his works, and took part in the conspiracy to rescue Germany by displacing the maniac and tyrant.?For this, he paid the forfeit of his life. In the sombre wars of modern democracy, chivalry finds no place ? Still, I do not regret or retract the tribute I paid to Rommel, unfashionable though it was judged.

Source: http://scuttlebuttstuch.tumblr.com/post/47214608140

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